@prefix foaf: .
@prefix wikipedia-en: .
@prefix ns2: .
wikipedia-en:Riociguat foaf:primaryTopic ns2:Riociguat .
@prefix ns3: .
ns2:Soluble_guanylyl_cyclase ns3:wikiPageWikiLink ns2:Riociguat .
ns3:wikiPageWikiLink ns2:Riociguat .
ns2:Cinaciguat ns3:wikiPageWikiLink ns2:Riociguat .
@prefix rdf: .
@prefix owl: .
ns2:Riociguat rdf:type owl:Thing .
@prefix wikidata: .
ns2:Riociguat rdf:type wikidata:Q8386 .
@prefix ns7: .
ns2:Riociguat rdf:type ns7:ChemicalObject ,
ns3:Drug ,
ns3:ChemicalSubstance ;
owl:sameAs ,
,
.
@prefix dbpedia-fr: .
ns2:Riociguat owl:sameAs dbpedia-fr:Riociguat ,
wikidata:Q2154494 .
@prefix dbpedia-id: .
ns2:Riociguat owl:sameAs dbpedia-id:Riociguat ,
.
@prefix dbpedia-sr: .
ns2:Riociguat owl:sameAs dbpedia-sr:Riociguat ,
.
@prefix dbpedia-de: .
ns2:Riociguat owl:sameAs dbpedia-de:Riociguat ,
.
@prefix yago-res: .
ns2:Riociguat owl:sameAs yago-res:Riociguat .
@prefix dbpedia-it: .
ns2:Riociguat owl:sameAs dbpedia-it:Riociguat .
@prefix dbpedia-es: .
ns2:Riociguat owl:sameAs dbpedia-es:Riociguat .
@prefix dbpedia-sh: .
ns2:Riociguat owl:sameAs dbpedia-sh:Riociguat ,
.
@prefix dbr: .
ns2:Riociguat owl:sameAs dbr:Riociguat .
@prefix rdfs: .
ns2:Riociguat rdfs:label "Riociguat"@fr ,
"Riociguat"@es ,
"\u0631\u064A\u0648\u0643\u064A\u063A\u0648\u062A"@ar ,
"Riociguat"@it ,
"\u30EA\u30AA\u30B7\u30B0\u30A2\u30C8"@ja ,
"Riociguat"@en ,
"Riociguat"@in ,
"Riociguat"@de .
@prefix dct: .
@prefix ns19: .
ns2:Riociguat dct:subject ns19:Pyrazolopyridines ,
ns19:Drugs_developed_by_Bayer ,
ns19:Carbamates ,
ns19:Organofluorides ,
ns19:Soluble_guanylate_cyclase_stimulators ,
ns19:Pyrimidines ;
foaf:depiction ,
.
@prefix prov: .
ns2:Riociguat prov:wasDerivedFrom .
@prefix gold: .
ns2:Riociguat gold:hypernym ns2:Drug ;
foaf:isPrimaryTopicOf wikipedia-en:Riociguat .
@prefix ns22: .
ns2:Riociguat ns22:stdinchi 1 ;
ns3:fdaUniiCode "RU3FE2Y4XI" ;
ns22:smiles "c14ncccc4cnn1Cc3ccccc3F"@en ;
ns3:casNumber "625115-55-1" ;
ns22:o 2 ;
ns22:stdinchikey "WXXSNCNJFUAIDG-UHFFFAOYSA-N"@en ;
ns22:chemspiderid 9479719 ;
ns22:iupacName "Methyl N-[4,6-Diamino-2-[1-[methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-N-methyl-carbaminate"@en ;
ns22:verifiedfields "changed"@en ;
ns22:atcPrefix "2.0"^^ ;
ns22:c 20 ;
ns22:h 19 ;
ns22:casNumber 625115 ;
ns22:routesOfAdministration ns2:Oral_administration ;
ns22:unii "RU3FE2Y4XI"@en ;
ns22:verifiedrevid 455344444 ;
ns22:displayAuthors 6 ;
ns22:nameListStyle "vanc"@en ;
ns22:atcSuffix "KX05"@en .
@prefix dbd: .
ns2:Riociguat ns22:bioavailability "94.0"^^dbd:perCent ;
ns22:chebi 76018 ;
ns22:drugbank "DB08931"@en ;
ns22:eliminationHalfLife "25200.0"^^dbd:second ;
ns22:kegg "D09572"@en ;
ns22:legalAu "S4"@en ;
ns22:legalUs "Rx-only"@en ;
ns22:tradename "Adempas"@en .
@prefix xsd: .
ns2:Riociguat ns3:bioavailability "94.0"^^xsd:float ;
ns3:chEBI "76018" ;
ns3:drugbank "DB08931" ;
ns3:kegg "D09572" ;
ns22:watchedfields "changed"@en ;
ns22:dailymedid "Riociguat"@en ;
ns22:metabolism ns2:CYP2J2 ,
ns2:CYP1A1 ,
ns2:CYP3A4 ,
ns2:CYP2C8 ;
ns22:proteinBound "95.0"^^dbd:perCent ;
ns22:metabolites "N-desmethylriociguat , glucuronide"@en ;
ns22:iupharLigand 5257 ;
ns22:legalEu "Rx-only"@en ;
ns22:synonyms "BAY 63-2521"@en .
@prefix ns25: .
ns2:Riociguat ns3:wikiPageExternalLink ns25:riociguat ;
ns3:thumbnail ;
ns22:image "Riociguat-3D-balls.png"@en ;
ns22:pregnancyAu "X"@en ;
ns22:n 8 ;
ns22:width 160 ;
ns22:alt "Ball-and-stick model of riociguat"@en ,
"Skeletal formula of riociguat"@en ;
ns3:wikiPageWikiLink ns2:National_Institutes_of_Health ,
ns2:Glucuronide ,
ns2:Cyclic_guanosine_monophosphate ,
ns2:Contractility ,
ns2:Death ,
ns2:Soluble_guanylate_cyclase ,
,
ns19:Organofluorides ,
ns2:Heterodimers ,
ns19:Bayer_brands ,
ns2:CGMP-dependent_protein_kinase ,
ns2:Tobacco_smoking ,
ns2:Nitric_oxide ,
ns2:Chronic_thromboembolic_pulmonary_hypertension ,
ns2:Pharmacokinetic ,
,
ns2:Micromolar ,
ns2:Endothelin_receptor_antagonist ,
ns2:Proof-of-concept ,
ns2:Kidney ,
ns2:Actin ,
ns19:Pyrimidines ,
ns2:Idiopathic_interstitial_pneumonia ,
ns2:World_Health_Organization ,
ns2:Pharmacodynamics ,
ns2:Interstitial_lung_disease ,
ns2:CYP2C8 ,
ns2:Haem ,
ns2:Indazole ,
ns2:CYP2J2 ,
ns2:Phosphodiesterase_inhibitor ,
ns2:Bile_duct ,
ns2:Generic_medication ,
ns2:Medication ,
ns2:Oral_administration ,
ns19:Pyrazolopyridines ,
ns2:Gastrointestinal_disorder ,
ns19:Vasodilators ,
ns2:CYP1A1 ,
ns2:Right_heart_hypertrophy ,
ns2:Ventricular_remodelling ,
ns2:PDE5_inhibitor ,
ns2:Endothelial_NOS ,
ns2:Placebo ,
ns2:Cytochrome ,
ns2:Fetal ,
ns2:Cinaciguat ,
ns2:CYP3A4 ,
ns2:Calcium ,
ns2:Myosin ,
ns19:Carbamates ,
ns2:Sildenafil ,
ns2:Pulmonary_arterial_hypertension ,
ns2:Pulmonary_hypertension ,
ns2:Dyspnea ,
ns2:Cytosolic ,
ns2:Vasodilation ,
,
ns2:Bayer ;
ns3:description "\u0645\u0631\u0643\u0628 \u0643\u064A\u0645\u064A\u0627\u0626\u064A"@ar ,
"\u0445\u0438\u043C\u0438\u0447\u0435\u0441\u043A\u043E\u0435 \u0441\u043E\u0435\u0434\u0438\u043D\u0435\u043D\u0438\u0435"@ru ,
"composito chimic"@ia ,
"cumpostu ch\u00ECmicu"@scn ,
"gemyske ferbining"@fy ,
"chemical compound"@en ,
"cheemesch Verbindung"@lb ,
"chemick\u00E1 slou\u010Denina"@cs ,
"component quimic"@oc ,
"\u0445\u0456\u043C\u0456\u0447\u043D\u0430 \u0441\u043F\u043E\u043B\u0443\u043A\u0430"@uk ,
"keemiline \u00FChend"@et ,
"chemick\u00E1 zl\u00FA\u010Denina"@sk ,
"komponim kimik"@sq ,
"chemiese verbinding"@af ,
"kediad kimiek"@br ,
"kjemisk sambinding"@nn ,
"composto qu\u00EDmico"@gl ,
"compuesto quimico"@an ,
"\u0584\u056B\u0574\u056B\u0561\u056F\u0561\u0576 \u0574\u056B\u0561\u0581\u0578\u0582\u0569\u0575\u0578\u0582\u0576"@hy ,
"\u0445\u0435\u043C\u0438\u0441\u043A\u043E \u0441\u043E\u0435\u0434\u0438\u043D\u0435\u043D\u0438\u0435"@mk ,
"kemiala kompozajo"@io ,
"\u05EA\u05E8\u05DB\u05D5\u05D1\u05EA"@iw ,
"compuestu qu\u00EDmicu"@ast ,
"composto qu\u00EDmico"@pt ,
"konposatu kimiko"@eu ,
"compus chimic"@ro ,
"senyawa kimia"@in ,
"compositum chemicum"@la ,
"composto chimico"@it ,
"cyfansoddyn cemegol"@cy ,
"\u03C7\u03B7\u03BC\u03B9\u03BA\u03AE \u03AD\u03BD\u03C9\u03C3\u03B7"@el ,
"Kompoz\u00E9 chimik"@gcr ,
"\u0445\u0438\u043C\u0438\u0447\u043D\u043E \u0441\u044A\u0435\u0434\u0438\u043D\u0435\u043D\u0438\u0435"@bg ,
"\u5316\u5408\u7269"@zh ,
"kemia kombina\u0135o"@eo ,
"m\u00E9dicament"@fr ,
"\u06A9\u06CC\u0656\u0645\u06CC\u0672\u06CC\u06CC \u0645\u064F\u0631\u064E\u06A9\u064E\u0628"@ks ,
"kemisk forbindelse"@da ,
"\u0D30\u0D3E\u0D38\u0D38\u0D02\u200C\u0D2F\u0D41\u0D15\u0D4D\u0D24\u0D02"@ml ,
"Arzneistoff"@de ,
"\u09B0\u09BE\u09B8\u09BE\u09AF\u09BC\u09A8\u09BF\u0995 \u09AF\u09CC\u0997"@bn ,
"conposto ch\u00ECmego"@vec ,
"compuesto qu\u00EDmico"@es ,
"\u0445\u0456\u043C\u0456\u0447\u043D\u0430\u0435 \u0437\u043B\u0443\u0447\u044D\u043D\u043D\u0435"@be ,
"chemische verbinding"@nl ,
"kemiallinen yhdiste"@fi ,
"\u0137\u012Bmisks savienojums"@lv ,
"compost qu\u00EDmic"@ca ,
"zwi\u0105zek chemiczny"@pl ,
"\u5316\u5408\u7269"@yue .
@prefix ns26: .
ns2:Riociguat ns22:wikiPageUsesTemplate ns26:Portal_bar ,
ns26:Use_dmy_dates ,
ns26:Vague ,
ns26:Authority_control ,
ns26:Drugbankcite ,
,
ns26:Ebicite ,
ns26:Keggcite ,
ns26:Short_description ,
ns26:Fdacite ,
ns26:Infobox_drug ,
ns26:Cascite ,
ns26:Stdinchicite ,
ns26:Reflist ,
ns26:Chemspidercite ,
ns26:Cs1_config ,
ns26:PAH_rx ,
ns26:Nitric_oxide_signaling ;
ns3:alternativeName "Adempas"@en ;
ns22:f 1 ;
ns22:excretion 48 ,
33 .
ns2:Sildenafil ns3:wikiPageWikiLink ns2:Riociguat .
ns2:Pulmonary_hypertension ns3:wikiPageWikiLink ns2:Riociguat .
ns2:Chronic_thromboembolic_pulmonary_hypertension ns3:wikiPageWikiLink ns2:Riociguat .
ns2:Balloon_pulmonary_angioplasty ns3:wikiPageWikiLink ns2:Riociguat .
ns2:ATC_code_C02 ns3:wikiPageWikiLink ns2:Riociguat .
ns2:Adempas ns3:wikiPageWikiLink ns2:Riociguat ;
ns3:wikiPageRedirects ns2:Riociguat .
ns2:BAY_63-2521 ns3:wikiPageWikiLink ns2:Riociguat ;
ns3:wikiPageRedirects ns2:Riociguat .