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Agonists and antagonists of 5-HT3 receptors

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Image Cardiovascular Pharmacology of 5-Hydroxytryptamine

Abstract

There can be little doubt that the basis of the recent remarkable advances in our understanding of the physiological and pathophysiological roles of 5-HT has been the identification and development of compounds with selectivity for 5-HT receptor subtypes [1–4]. Among these, none has been more spectacular nor of potentially greater therapeutic significance than the advent of ligands with potency and selectivity for the 5-HT3 receptor subtype. The purpose of this article is to describe these compounds and their use as tools to identify 5-HT3 receptors and their properties. Both selective agonists and antagonists will be considered as well as a number of their radiolabeled counterparts. The historical development of these compounds will not be dealt with since it has been the subject of recent comprehensive review [5–8].

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Authors
  1. John R. Fozard
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Editors and Affiliations

  1. Department of Pharmacology, Erasmus University, Rotterdam, The Netherlands

    P. R. Saxena

  2. Department of Physiology, University of Wales, College of Cardiff, Cardiff, UK

    D. I. Wallis

  3. Department of Pharmacology, Duphar B.V, Weesp, The Netherlands

    W. Wouters & P. Bevan & 

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Fozard, J.R. (1990). Agonists and antagonists of 5-HT3 receptors. In: Saxena, P.R., Wallis, D.I., Wouters, W., Bevan, P. (eds) Cardiovascular Pharmacology of 5-Hydroxytryptamine. Developments in CardioCardiovascular Pharmacology of 5-Hydroxytryptamine, vol 106. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0479-8_8

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  • DOI: https://doi.org/10.1007/978-94-009-0479-8_8

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6701-0

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