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Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor

Nature volume 377, pages 397–404 (1995) Cite this article

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Abstract

Thyroid-hormone and retinoic-acid receptors exert their regulatory functions by acting as both activators and repressers of gene expression. A nuclear receptor co-repressor (N-CoR) of relative molecular mass 270K has been identified which mediates ligand-independent inhibition of gene transcription by these receptors, suggesting that the molecular mechanisms of repression by thyroid-hormone and retinoic-acid receptors are analogous to the co-repressor-dependent transcriptional inhibitory mechanisms of yeast and Drosophila.

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Authors and Affiliations

  1. Howard Hughes Medical Institute, University of California, San Diego, La Jolla, California, 92093-0648, USA

    Andreas J. Hörlein, Anders M. Näär, Thorsten Heinzel, Joseph Torchia, Bernd Gloss, Aimee Ryan, Yasutomi Kamei & Michael G. Rosenfeld

  2. Cellular and Molecular Medicine, Department and School of Medicine, University of California, San Diego, La Jolla, California, 92093-0648, USA

    Riki Kurokawa, Mats Söderström & Christopher K. Glass

  3. Graduate Program in Molecular Pathology, Department and School of Medicine, University of California, San Diego, La Jolla, California, 92093-0648, USA

    Anders M. Näär

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  1. Andreas J. Hörlein
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  2. Anders M. Näär
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Hörlein, A., Näär, A., Heinzel, T. et al. Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature 377, 397–404 (1995). https://doi.org/10.1038/377397a0

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