Glucose-1-phosphate cytidylyltransferase
| Glucose-1-phosphate cytidylyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.7.33 | ||||||||
| CAS no. | 9027-10-5 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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Glucose-1-phosphate cytidylyltransferase (EC 2.7.7.33) is an enzyme that catalyzes the chemical reaction
The enzyme characterised from Salmonella paratyphi combines cytidine triphosphate and glucose 1-phosphate to give cytidine diphosphate glucose, with pyrophosphate (PPi) as a byproduct.[1][2][3]
This enzyme is a transferase, specifically one transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is CTP:alpha-D-glucose-1-phosphate cytidylyltransferase. Other names in common use include CDP glucose pyrophosphorylase, cytidine diphosphoglucose pyrophosphorylase, cytidine diphosphate glucose pyrophosphorylase, cytidine diphosphate-D-glucose pyrophosphorylase, and CTP:D-glucose-1-phosphate cytidylyltransferase.[4]
Structural studies
[edit]As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes PDB: 1TZF and PDB: 1WVC.
References
[edit]- ↑ Mayer RM, Ginsburg V (1965). "Purification and Properties of Cytidine Diphosphate D-Glucose Pyrophosphorylase from Salmonella paratyphi A". J. Biol. Chem. 240 (5): 1900–4. doi:10.1016/S0021-9258(18)97402-8. PMID 14299608.
- ↑ Xue M. He & Hung-wen Liu (2002). "Formation of unusual sugars: Mechanistic studies and biosynthetic applications". Annu Rev Biochem. 71: 701–754. doi:10.1146/annurev.biochem.71.110601.135339. PMID 12045109.
- ↑ Samuel G, Reeves P (2003). "Biosynthesis of O-antigens: genes and pathways involved in nucleotide sugar precursor synthesis and O-antigen assembly". Carbohydr. Res. 338 (23): 2503–19. doi:10.1016/j.carres.2003.07.009. PMID 14670712.
- ↑ Enzyme 2.7.7.33 at KEGG Pathway Database.
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