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Alteration of behavioural changes induced by 3,4,5-trimethoxyphenylethylamine (mescaline) by pretreatment with 2,4,5-trimethoxyphenylethylamine

A self-experiment

  • Original Investigations
  • Human Pharmacology
  • Published: September 1971
  • Volume 21, pages 229–237 (1971)
  • Cite this article

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Alteration of behavioural changes induced by 3,4,5-trimethoxyphenylethylamine (mescaline) by pretreatment with 2,4,5-trimethoxyphenylethylamine
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  • A. Dittrich1 
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  • 11 Citations

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Abstract

In this self-experiment, conducted under double-blind conditions using several psychological tests to assess drug effects, it was found that the pre-treatment with 2,4,5-trimethoxyphenylethylamine potentiates the effects of mescaline (3,4,5-trimethoxyphenylethylamine).

2,4,5-trimethoxyphenylethylamine alone proved to have no psychotomimetic properties.

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References

  • Balestrieri, A.: Patologia mentale e farmacologia. Padova: Cedam 1961.

    Google Scholar 

  • Bellak, L., Chassan, J. B.: An approach to the evaluation of drug effect during psychotherapy: a double-blind study of a single case. J. nerv. ment. Dis. 139, 20–30 (1964).

    PubMed  Google Scholar 

  • Brickenkamp, R.: Test d2 — Aufmerksamkeits Belastungstest Handanweisung, 2. Aufl. Göttingen: Hogrefe 1967.

    Google Scholar 

  • Clark, L. D., Bliss, E. L.: Psychopharmacological studies of LSD-25 intoxication. Arch. Keurol. Psychiat. (Chic.) 81, 348–359 (1959).

    Google Scholar 

  • —, Nakashima, E. N.: Experimental studies of marihuana. Amer. J. Psychiat. 125, 379–384 (1968).

    Google Scholar 

  • Chassan, J. B.: Statistical inference and the single case in clinical design. Psychiatry 23, 173–184 (1960).

    PubMed  Google Scholar 

  • Deniker, P. J.: Biological changes in man following intravenous administration of mescaline. J. nerv. ment. Dis. 125, 427–431 (1957).

    PubMed  Google Scholar 

  • Heimann, H.: Ausdrucksphänomenologie der Modellpsychosen (Psilocybin). Psychiat. et Neurol. (Basel) 141, 69–100 (1961).

    Google Scholar 

  • —: Essai d'objectivation expérimentale et clinique de l'émotionnalité. Schweiz. Arch. Neurol. Neurochir. Psychiat. 100, 475–486 (1967).

    Google Scholar 

  • - Personal communication (1970).

  • Hoffer, A., Osmond, H.: The hallucinogens. New York: Academic Press 1967.

    Google Scholar 

  • Jones, R. T., Stone, G. C.: Psychological studies of marihuana and alcohol in man. Psychopharmacologia (Berl.) 18, 108–117 (1970).

    Google Scholar 

  • Kristof, W.: Eine Faktorenanalyse geometrisch-optischer Täuschungen. Z. exp. angew. Psychol. 10, 583–596 (1963).

    Google Scholar 

  • Meldman, M. J.: The quantitative analysis of anxiety and depression. Psychosomatics 6, 8–15 (1965).

    Google Scholar 

  • Obermair, W.: Personal communication (1970).

  • Smythies, J. R., Benington, F., Morin, R. D., Clark, L. C.: Structure-activity relationship studies on mescaline. III. The influence of the methoxy groups. Psychopharmacologia (Berl.) 10, 379–387 (1967a).

    Google Scholar 

  • —, Johnston, V. S., Bradley, R. J.: Alteration by pretreatment with iproniazid and an inactive mescaline analogue of a behaviour change by mescaline. Nature (Lond.) 216, 196–197 (1967b).

    Google Scholar 

  • Theobald, W., Buech, O., Kunz, H. A., Krupp, P., Stenger, E. G., Heimann, H.: Pharmakologische und experimentalpsychologische Untersuchungen mit 2 Inhaltsstoffen des Fliegenpilzes (Amanita Muscaria). Arzneimittel-Forsch. (Drug Res.) 18, 311–315 (1968).

    Google Scholar 

  • Wikler, A.: Clinical and electroencephalographic studies on the effects of mescaline, N-allylnormorphine and morphine in man. J. nerv. ment. Dis. 120, 157–175 (1954).

    PubMed  Google Scholar 

  • Wolbach, A. B., Isbell, H., Miner, E. J.: Cross tolerance between mescaline and LSD-25. With a comparison of the mescaline and LSD reactions. Psychopharmacologia (Berl.) 3, 1–14 (1962).

    Google Scholar 

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Authors and Affiliations

  1. Division of Research, Psychiatric University Clinic ‘Burghölzli’, Zürich

    A. Dittrich

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  1. A. Dittrich
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Dittrich, A. Alteration of behavioural changes induced by 3,4,5-trimethoxyphenylethylamine (mescaline) by pretreatment with 2,4,5-trimethoxyphenylethylamine. Psychopharmacologia 21, 229–237 (1971). https://doi.org/10.1007/BF00403861

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  • Received: 12 January 1971

  • Issue date: September 1971

  • DOI: https://doi.org/10.1007/BF00403861

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Key-Words

  • Antagonism
  • Mescaline
  • 2,4,5-Trimethoxyphenylethylamine
  • Potentiation

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