Thalidomide
 | |
| Amazina | |
|---|---|
| Amazina y'ubucuruzi | Contergan, Thalomid, n'indi |
| Amakuru y'ubuvuzi | |
| Uko ufatwa | Mu kanwa |
| Ihuza ryo hanze | |
| MedlinePlus | a699032 |
| Ibiranga | |
| CAS Number | |
| PubChem CID | |
| DrugBank | |
| UNII | |
| KEGG | |
| ChEMBL | |
| Kode ya ATC |
|
| Amakuru y'ubutabire | |
| Formule | C13H10N2O4 |
| Uburemere bwa mole | 258233 g·mol−1 |
Thalidomide, igurishwa ku mazina nka Thalomid na Contergan, ni umuti ukoreshwa uyu munsi mu kuvura kanseri zimwe na zimwe (nka multiple myeloma) n'ingorane z'ibibembe.
Yashyizwe ku isoko mu 1957 mu Budage, iza kumenyekana cyane kubera ubumuga bukomeye yateye abana b'ababyeyi bayifashe batwite.
Ikoreshwa mu buvuzi
[Hindura | hindura inkomoko],_1960.jpg)
Thalidomide, igurishwa ku izina ry’ikirango cya Thalomid n’indi, ni umuti ukoreshwa mu kuvura kanseri zitandukanye zirimo indwara ya myeloma nyinshi, indwara ya graft-versus-host, hamwe n’indwara nyinshi z’uruhu zirimo n’ingorane z’ibibembe.[1] Nubwo yakoreshejwe mu ndwara zitandukanye zifitanye isano na virusi itera SIDA, ikoreshwa nk'iryo rifitanye isano no kwiyongera kwa virusi.[1] Ifatwa mu kanwa.[1]
Ingaruka mbi n'uko ikora
[Hindura | hindura inkomoko]Ingaruka mbi zikunze kugaragara zirimo gusinzira, kurwara ibisebe no kuzerera.[1] Ingaruka mbi zikomeye zirimo indwara ya tumor lysis syndrome, kuzura kw'amaraso, no kurwara indwara z'imitsi yo mu gice cy'umubiri.[2] Gukoresha iyo utwite bishobora kwangiza umwana, harimo no gutuma ingingo z'umubiri zihinduka nabi.[1] Ku bagabo bafata imiti, agakingirizo ni byiza niba abo bashakanye bashobora gutwita.[2] Ni umuti uvura ubudahangarwa bw'umubiri kandi ukorana n'uburyo butandukanye burimo gukangura uturemangingo twa T no kugabanya ikorwa rya TNF-α.[1]
Amateka
[Hindura | hindura inkomoko]Thalidomide yashyizwe ku isoko bwa mbere mu 1957 mu Budage bw'Iburengerazuba, aho yabonekaga ku giciro cyayo.[3][4] Ubwo yasohorwaga bwa mbere, thalidomide yatewe inkunga yo guhangayika, gusinzira nabi, "guhangayika", no gusara mu gitondo.[4][5] Nubwo byagaragaye ko ari byiza mu gihe cyo gutwita, impungenge ku bijyanye n'ubumuga bwo kuvukana zagaragaye mu 1961 maze imiti ikurwa ku isoko mu Burayi muri uwo mwaka.[4][3] Umubare w’abantu bose bagizweho ingaruka n’ikoreshwa ry’iyi mashini mu gihe cyo gutwita ubarirwa mu 10.000, muri bo abagera kuri 40% bapfuye ahagana mu gihe cyo kuvuka.[4][1] Abarokotse bari bafite ibibazo by'amaguru, amaso, inzira z'inkari n'umutima.[3] Kwinjira kwayo ku isoko rya Amerika byabujijwe na Frances Kelsey wo muri FDA.[5] Ubusembwa bw'imiti ya thalidomide bwatumye habaho iterambere ry'amategeko n'igenzura ry'imiti mu bihugu byinshi.[5][3]
Muri iki gihe
[Hindura | hindura inkomoko]Yemejwe gukoreshwa mu buvuzi muri Leta Zunze Ubumwe za Amerika mu 1998.[1] Iri ku rutonde rw'imiti y'ingenzi y'Umuryango w'Abibumbye wita ku Buzima . Iraboneka nk'umuti usanzwe.[2] Mu Bwongereza, NHS itwara amafaranga agera kuri £1,194 ku kwezi guhera mu 2018.[2] Aya mafaranga muri Leta Zunze Ubumwe za Amerika agura hafi amadolari y'Amerika 9,236 kugeza mu 2019.[6]
Inyandiko
[Hindura | hindura inkomoko]- 1 2 3 4 5 6 7 8 "Thalidomide Monograph for Professionals". Drugs.com (in Icyongereza). Archived from the original on 10 September 2012. Retrieved 14 November 2019.
- 1 2 3 4 British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 936. ISBN 9780857113382.
- 1 2 3 4 Cuthbert, Alan (2003). The Oxford Companion to the Body. Oxford University Press. p. 682. doi:10.1093/acref/9780198524038.001.0001. ISBN 9780198524038.
- 1 2 3 4 Miller, Marylin T. (1991). "Thalidomide Embryopathy: A Model for the Study of Congenital Incomitant Horizontal Strabismus". Transactions of the American Ophthalmological Society. 81: 623–674. PMC 1298636. PMID 1808819.
- 1 2 3 Loue, Sana; Sajatovic, Martha (2004). Encyclopedia of Women's Health (in Icyongereza). Springer Science & Business Media. p. 644. ISBN 9780306480737. Archived from the original on 2021-08-29. Retrieved 2019-11-15.
- ↑ "Thalomid Prices, Coupons & Patient Assistance Programs". Drugs.com (in Icyongereza). Archived from the original on 30 December 2019. Retrieved 15 November 2019.
Reba kandi
[Hindura | hindura inkomoko]Ingingo zijyanye
[Hindura | hindura inkomoko]Ihuza ryo hanze
[Hindura | hindura inkomoko]- "Thalidomide". MedlinePlus (in Icyongereza).
