Эчтәлеккә күчү

CCL20

Wikipedia — ирекле энциклопедия проектыннан ([http://tt.wikipedia.org.ttcysuttlart1999.aylandirow.tmf.org.ru/wiki/CCL20 latin yazuında])
CCL20
Нинди таксонда бар H. sapiens[1]
Кодлаучы ген CCL20[d][1]
Молекуляр функция cytokine activity[d][2][2], связывание с белками плазмы[d][3][4][5], CCR6 chemokine receptor binding[d][2][6][7], chemokine activity[d][8][2][9] һәм CCR chemokine receptor binding[d][9]
Күзәнәк компоненты күзәнәк тышындагы өлкә[d][2][2][2], внутренний компонент клетки[d][10] һәм күзәнәк тышындагы мохит[d][11][2][9]
Биологик процесс monocyte chemotaxis[d][9], positive regulation of T cell migration[d][12], neutrophil chemotaxis[d][9], positive regulation of ERK1 and ERK2 cascade[d][9], positive regulation of GTPase activity[d][9], positive regulation of nitric-oxide synthase biosynthetic process[d][10], defense response to bacterium[d][2], передача сигнала между клетками[d][11], lymphocyte chemotaxis[d][9], Заживление ран[d][10], cellular response to lipoteichoic acid[d][10], cellular response to tumor necrosis factor[d][9], cellular response to organic substance[d][10], chemokine-mediated signaling pathway[d][9], cellular response to interleukin-1[d][9], cellular response to interferon-gamma[d][9], передача сигнала[d][11], иммун җавап[d][13][2], cellular response to lipopolysaccharide[d][10], хемотаксис[d][8][2][2][…], calcium-mediated signaling using intracellular calcium source[d][14], cell chemotaxis[d][15], T cell migration[d][2][2], thymocyte migration[d][2][2], воспалительная реакция[d][16][2][9], antimicrobial humoral immune response mediated by antimicrobial peptide[d][17][18], regulation of signaling receptor activity[d][2], G protein-coupled receptor signaling pathway[d][2][9] һәм cytokine-mediated signaling pathway[d][2]
Изображение Gene Atlas

CCL20 (ингл. ) — аксымы, шул ук исемдәге ген тарафыннан кодлана торган югары молекуляр органик матдә.[19][20]

  1. 1 2 UniProt
  2. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 GOA
  3. ↑ Jeang K., Iha H., Ikeda F. et al. Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappaB activation // EMBO J. — NPG, 2008. — ISSN 0261-4189; 1460-2075 — doi:10.1038/EMBOJ.2008.5 — PMID:18239685
  4. ↑ Hundelshausen P. V., Grommes J., Weber C. et al. Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation // Sci. Transl. Med. — AAAS, 2017. — ISSN 1946-6234; 1946-6242 — doi:10.1126/SCITRANSLMED.AAH6650 — PMID:28381538
  5. ↑ Shembade N., Harhaj N. S., Liebl D. J. et al. Essential role for TAX1BP1 in the termination of TNF-alpha-, IL-1- and LPS-mediated NF-kappaB and JNK signaling // EMBO J. — NPG, 2007. — ISSN 0261-4189; 1460-2075 — doi:10.1038/SJ.EMBOJ.7601823 — PMID:17703191
  6. ↑ Ai L., Liao F. Mutating the four extracellular cysteines in the chemokine receptor CCR6 reveals their differing roles in receptor trafficking, ligand binding, and signaling // Biochemistry — ACS, 2002. — ISSN 0006-2960; 1520-4995; 1943-295X — doi:10.1021/BI025855Y — PMID:12081481
  7. ↑ Röhrl J., Yang D., Oppenheim J. J. et al. Specific binding and chemotactic activity of mBD4 and its functional orthologue hBD2 to CCR6-expressing cells // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2010. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.M109.091090 — PMID:20068036
  8. 1 2 D Yang, Howard O. M., Q Chen et al. Cutting edge: immature dendritic cells generated from monocytes in the presence of TGF-beta 1 express functional C-C chemokine receptor 6 // J. Immunol. — Baltimore: 1999. — ISSN 0022-1767; 1550-6606 — PMID:10438902
  9. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 Livstone M. S., Thomas P. D., Lewis S. E. et al. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium // Brief. Bioinform. — OUP, 2011. — ISSN 1467-5463; 1477-4054 — doi:10.1093/BIB/BBR042 — PMID:21873635
  10. 1 2 3 4 5 6 GOA
  11. 1 2 3 Nomiyama H. Molecular cloning of a novel human CC chemokine liver and activation-regulated chemokine (LARC) expressed in liver. Chemotactic activity for lymphocytes and gene localization on chromosome 2 // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 1997. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.272.9.5846 — PMID:9038201
  12. ↑ Chiang Y., Lee F. S. CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration // PLOS ONE / PLOS ONE Editors — PLoS, 2013. — ISSN 1932-6203 — doi:10.1371/JOURNAL.PONE.0061761 — PMID:23620790
  13. ↑ Howard O. M., O Chertov Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6 // Science / H. Thorp — Northern America: AAAS, 1999. — ISSN 0036-8075; 1095-9203 — doi:10.1126/SCIENCE.286.5439.525 — PMID:10521347
  14. ↑ Fok E., Chen H., Ng C. Deficient human β-defensin 1 underlies male infertility associated with poor sperm motility and genital tract infection // Sci. Transl. Med. — AAAS, 2014. — ISSN 1946-6234; 1946-6242 — doi:10.1126/SCITRANSLMED.3009071 — PMID:25122636
  15. ↑ Buffone M. G., Benencia F., Conejo-García J. R. et al. A role for the chemokine receptor CCR6 in mammalian sperm motility and chemotaxis // J. Cell. Physio. — Wiley, 2014. — ISSN 0021-9541; 1097-4652 — doi:10.1002/JCP.24418 — PMID:23765988
  16. ↑ R. Hromas, Gray P. W., D. Chantry et al. Cloning and characterization of exodus, a novel beta-chemokine // Blood — American Society of Hematology, Elsevier, 1997. — ISSN 0006-4971; 1528-0020 — PMID:9129037
  17. ↑ Moser B., Wolf M., Mühlemann K. Potent and broad-spectrum antimicrobial activity of CXCL14 suggests an immediate role in skin infections // J. Immunol. — Baltimore: 2009. — ISSN 0022-1767; 1550-6606 — doi:10.4049/JIMMUNOL.182.1.507 — PMID:19109182
  18. ↑ Yang D., Chen Q., Hoover D. M. et al. Many chemokines including CCL20/MIP-3alpha display antimicrobial activity // J. Leukoc. Biol. / L. Montaner — Wiley-Blackwell, 2003. — ISSN 0741-5400; 1938-3673 — doi:10.1189/JLB.0103024 — PMID:12949249
  19. ↑ HUGO Gene Nomenclature Commitee, HGNC:29223 (ингл.). әлеге чыганактан 2015-10-25 архивланган. 18 сентябрь, 2017 тикшерелгән.
  20. ↑ UniProt, Q9ULJ7 (ингл.). 18 сентябрь, 2017 тикшерелгән.
  • Степанов В.М. (2005). Молекулярная биология. Структура и функция белков. Москва: Наука. ISBN 5-211-04971-3.(рус.)
  • Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002). Molecular Biology of the Cell (вид. 4th). Garland. ISBN 0815332181.(ингл.)