Hypercoag Disorders

What is it?
Activation problems
Regulation problems
Breakdown problems
Other factors
Laboratory tests
Treatments
Sources

Problems with coagulation cascade regulation

Inherited:

Activated Protein C resistance (Factor V Leiden mutation) -- a mutation in the gene that makes the factor V protein. Factor V is activated normally, but it is resistant to degradation by activated Protein C, which regulates the clotting process.

Antithrombin (III) deficiency or dysfunction -- this is a factor that helps decrease the activity of the clotting process by inhibiting factors Xa, IXa, XIa, and thrombin. Inherited or acquired deficiency of antithrombin can lead to a clot formation.

Protein C deficiency or dysfunction -- Protein C helps regulate the speed of the coagulation cascade by degrading activated factors V and VIII.

Protein S deficiency or dysfunction -- Protein S is a cofactor with Protein C

Prothrombin 20210 mutation -- a mutation that results in an increased amount of thrombin (activated factor II) in the circulation, which is associated with an increased risk for venous blood clots.

Elevated factor VIII levels -- persistently elevated factor VIII levels that are not associated with inflammation or other acquired conditions but are associated with an increased thrombotic risk.

Acquired:

Antiphospholipid syndrome (lupus anticoagulant and anticardiolipin antibody)

Disseminated intravascular coagulation (DIC)

Bone marrow disorders such as myeloproliferative disorders

In very rare cases, antibodies to coagulation factors; most factor antibodies cause bleeding episodes, not clotting problems.

Systemic lupus erythematosus - an autoimmune disorder

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