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Cambridge, England, United Kingdom
3K followers 500+ connections

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About

AI and Data leader specialising in scaling high-growth tech organisations. T-shaped…

Experience & Education

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    Unmind

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Publications

  • Integration of Genomic Data Enables Selective Discovery of Breast Cancer Drivers

    Cell

    Identifying driver genes in cancer remains a crucial bottleneck in therapeutic development and basic understanding of the disease. We developed Helios, an algorithm that integrates genomic data from primary tumors with data from functional RNAi screens to pinpoint driver genes within large recurrently amplified regions of DNA. Applying Helios to breast cancer data identified a set of candidate drivers highly enriched with known drivers (p < 10−14). Nine of ten top-scoring Helios genes are…

    Identifying driver genes in cancer remains a crucial bottleneck in therapeutic development and basic understanding of the disease. We developed Helios, an algorithm that integrates genomic data from primary tumors with data from functional RNAi screens to pinpoint driver genes within large recurrently amplified regions of DNA. Applying Helios to breast cancer data identified a set of candidate drivers highly enriched with known drivers (p < 10−14). Nine of ten top-scoring Helios genes are known drivers of breast cancer, and in vitro validation of 12 candidates predicted by Helios found ten conferred enhanced anchorage-independent growth, demonstrating Helios’s exquisite sensitivity and specificity. We extensively characterized RSF-1, a driver identified by Helios whose amplification correlates with poor prognosis, and found increased tumorigenesis and metastasis in mouse models. We have demonstrated a powerful approach for identifying driver genes and how it can yield important insights into cancer.

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  • The miR-424(322)/503 cluster orchestrates remodeling of the epithelium in the involuting mammary gland

    Genes & Development

    The mammary gland is a very dynamic organ that undergoes continuous remodeling. The critical regulators of this process are not fully understood. Here we identify the microRNA cluster miR-424(322)/503 as an important regulator of epithelial involution after pregnancy. Through the generation of a knockout mouse model, we found that regression of the secretory acini of the mammary gland was compromised in the absence of miR-424(322)/503. Mechanistically, we show that miR-424(322)/503 orchestrates…

    The mammary gland is a very dynamic organ that undergoes continuous remodeling. The critical regulators of this process are not fully understood. Here we identify the microRNA cluster miR-424(322)/503 as an important regulator of epithelial involution after pregnancy. Through the generation of a knockout mouse model, we found that regression of the secretory acini of the mammary gland was compromised in the absence of miR-424(322)/503. Mechanistically, we show that miR-424(322)/503 orchestrates cell life and death decisions by targeting BCL-2 and IGF1R (insulin growth factor-1 receptor).

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  • An integrated approach to uncover drivers of cancer

    Cell

    We developed a computational framework that integrates chromosomal copy number and gene expression data for detecting aberrations that promote cancer progression. We demonstrate the utility of this framework using a melanoma data set. Our analysis correctly identified known drivers of melanoma and predicted multiple tumor dependencies.

    Other authors
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  • JISTIC: Identification of Significant Targets in Cancer

    BCM Bioinformatics

    We present JISTIC, a tool for analyzing datasets of genome-wide copy number variation to identify driver aberrations in cancer.

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Patents

  • Method to define and execute business metrics on unstructured processes

    Issued EU WO/2009/122156

    Other inventors
  • Automatic anomaly detection in business processes using fuzzy relationships

    Issued EU WO/2008/122753

    Other inventors
    • B Majeed
    • D Nauck

Honors & Awards

  • Research highlighted in list of top 10 most influential papers of 2015

    International Society for Computational Biology

    Helios (Cell, December, 2014) recognized as top 10 influential papers of the year by the
    International Society for Computational Biology

  • Fulbright scholarship

    Fulbright comission

    One of the 20 awardees of the Fulbright Scholarship grantes to Spanish scholars to pursue graduate studies in the United States.

  • IET Technology Awards 2007

    IET

    Winner of the 2007 IET Technology Awards as part of the Real Time Business Intelligence (RTBI) team

  • Finalist of the Vodafone Best Thesis Award 2005

    Vodafone

Languages

  • English

    Full professional proficiency

  • Spanish

    Native or bilingual proficiency

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