“I have worked with Felix when he was leading the data team at MindGym, he has been both a great partner for us building the technical infrastructure and the strategy for analysing large corpora of open text data as part of our new diagnostics products. Felix is an empathetic leader who has led the team of data engineers and scientists in rapidly developing large language models based on our intellectual property to solve the problems of our users and clients. He has always demonstrated a deep understanding of technical matters and the business problems to be solved and has been generally fantastic to work with. I would highly recommend Felix as a leader to anyone trying to solve complex data challenges.”
About
Experience & Education
Publications
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Integration of Genomic Data Enables Selective Discovery of Breast Cancer Drivers
Cell
Identifying driver genes in cancer remains a crucial bottleneck in therapeutic development and basic understanding of the disease. We developed Helios, an algorithm that integrates genomic data from primary tumors with data from functional RNAi screens to pinpoint driver genes within large recurrently amplified regions of DNA. Applying Helios to breast cancer data identified a set of candidate drivers highly enriched with known drivers (p < 10−14). Nine of ten top-scoring Helios genes are…
Identifying driver genes in cancer remains a crucial bottleneck in therapeutic development and basic understanding of the disease. We developed Helios, an algorithm that integrates genomic data from primary tumors with data from functional RNAi screens to pinpoint driver genes within large recurrently amplified regions of DNA. Applying Helios to breast cancer data identified a set of candidate drivers highly enriched with known drivers (p < 10−14). Nine of ten top-scoring Helios genes are known drivers of breast cancer, and in vitro validation of 12 candidates predicted by Helios found ten conferred enhanced anchorage-independent growth, demonstrating Helios’s exquisite sensitivity and specificity. We extensively characterized RSF-1, a driver identified by Helios whose amplification correlates with poor prognosis, and found increased tumorigenesis and metastasis in mouse models. We have demonstrated a powerful approach for identifying driver genes and how it can yield important insights into cancer.
Other authorsSee publication -
The miR-424(322)/503 cluster orchestrates remodeling of the epithelium in the involuting mammary gland
Genes & Development
The mammary gland is a very dynamic organ that undergoes continuous remodeling. The critical regulators of this process are not fully understood. Here we identify the microRNA cluster miR-424(322)/503 as an important regulator of epithelial involution after pregnancy. Through the generation of a knockout mouse model, we found that regression of the secretory acini of the mammary gland was compromised in the absence of miR-424(322)/503. Mechanistically, we show that miR-424(322)/503 orchestrates…
The mammary gland is a very dynamic organ that undergoes continuous remodeling. The critical regulators of this process are not fully understood. Here we identify the microRNA cluster miR-424(322)/503 as an important regulator of epithelial involution after pregnancy. Through the generation of a knockout mouse model, we found that regression of the secretory acini of the mammary gland was compromised in the absence of miR-424(322)/503. Mechanistically, we show that miR-424(322)/503 orchestrates cell life and death decisions by targeting BCL-2 and IGF1R (insulin growth factor-1 receptor).
Other authorsSee publication -
An integrated approach to uncover drivers of cancer
Cell
We developed a computational framework that integrates chromosomal copy number and gene expression data for detecting aberrations that promote cancer progression. We demonstrate the utility of this framework using a melanoma data set. Our analysis correctly identified known drivers of melanoma and predicted multiple tumor dependencies.
Other authorsSee publication -
JISTIC: Identification of Significant Targets in Cancer
BCM Bioinformatics
We present JISTIC, a tool for analyzing datasets of genome-wide copy number variation to identify driver aberrations in cancer.
Other authorsSee publication
Patents
Honors & Awards
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Research highlighted in list of top 10 most influential papers of 2015
International Society for Computational Biology
Helios (Cell, December, 2014) recognized as top 10 influential papers of the year by the
International Society for Computational Biology -
Fulbright scholarship
Fulbright comission
One of the 20 awardees of the Fulbright Scholarship grantes to Spanish scholars to pursue graduate studies in the United States.
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IET Technology Awards 2007
IET
Winner of the 2007 IET Technology Awards as part of the Real Time Business Intelligence (RTBI) team
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Finalist of the Vodafone Best Thesis Award 2005
Vodafone
Languages
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English
Full professional proficiency
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Spanish
Native or bilingual proficiency
Recommendations received
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