XtalPi Inc.

Swiss Biotech Day 2026 is around the corner! It's one of Europe's leading biotechnology gatherings, where the global life sciences community will come together in Basel. 📅 Date: May 4–5, 2026 📍 Venue: Congress Center Basel XtalPi's presence at the event will include: - Exhibition Booth #GV20 – We welcome you to stop by our booth for in-person conversations and explore potential collaboration. - One-to-One Partnering Meetings – Have focused discussions, productive exchanges with Yang Xie, Greg Prikler, Te Guo, Michael Bossert. - Panel Discussion – Yang Xie, VP & Head Of Proximity Induced Therapeutics Platforms of XtalPi will join a panel session on May 5 (Day 2), 14:45–15:15. We look forward to connecting with biotech leaders, investors, R&D professionals, and peers across the life sciences ecosystem to share insights, exchange ideas, and engage in open dialogue. #SwissBiotechAssociation #Biotech #LifeSciences #XtalPi #Basel

Dr. Jian Ma, Co-Founder & CEO of XtalPi, recently shared valuable insights at two premier top-tier North America-China exchange events: 2026 Harvard College China Forum and 2026 Yale U.S.-China Forum. At Harvard, during the opening remarks for the pitch competition, Dr. Ma reflected XtalPi's 12-year journey and highlighted two core mindsets for innovators: the courage to "burn the boats" and the agility to embrace change amid ongoing industry and market shifts. In his closing speech, he traced XtalPi's evolution from an MIT lab venture to a global leader in AI4S. Guided by the vision "AI+robots, making science better", XtalPi builds a data-driven closed-loop R&D system, now serving leading pharmaceutical companies worldwide and expanding to new energy and advanced materials. At Yale, Dr. Ma joined a fireside chat on "AI Beyond Answers", where he explored how AI is evolving from simple response generation to autonomous, long-cycle decision-making for real-world industrial and scientific challenges. Across both forums, Dr. Ma highlighted how innovation, paired with global collaboration, can drive meaningful progress across science and industry. XtalPi will continue to push the boundaries of AI-driven research and deepen partnerships across the global innovation ecosystem. 🌍 #AIforScience #Innovation #GlobalCollaboration #XtalPi #HarvardColleageChinaForum #YaleChinaForum #TechLeadership

✨Great day at #AACR2026! Our poster is on display & receiving fantastic feedback from the on-site audience. We’re excited to share that our poster, Single amino acid residue substitution to improve immunogenicity of HLA peptides targeting p53 neoantigen (Poster #4361), was jointly presented with Sequencio Therapeutics. It was on display in Poster Section 10, Board 1 during the Vaccine Platforms and Target Identification session (April 21, 9:00 AM–12:00 PM). This work showcases how XtalPi's PepiX™ AI platform enables rapid predict and design of p53 neoantigen-derived peptides, where single amino acid substitutions were used to significantly enhance immunogenicity across multiple humanized HLA alleles. Key findings validated in preclinical models: ✅ AI-designed modified peptides induced excellent and more durable CD8+ T cell responses compared to their parental counterparts ✅ The optimized neoepitopes showed improved cross-reactivity and anti-tumor potential, supporting their development for p53-driven cancer immunotherapies It was a pleasure connecting with so many fellow researchers and industry peers who stopped by for insightful discussions—thank you for the great conversations! 📌 Missed us onsite? Reach out anytime at pepix@xtalpi.com to explore how PepiX can accelerate your peptide immunotherapy and vaccine development programs. #AACR2026 #AACR #PeptideTherapeutics #Neoantigen #VaccineDevelopment #AIinDrugDiscovery #Oncology #Immunotherapy #XtalPi #PepiX

🚀 Live Webinar Alert: Join the event — Peptide Drug Hunting Consortium & XtalPi Live Webinar on Advances in Peptide Therapeutics. Co-hosted by XtalPi and PDHC, this session brings together global experts to unpack the future of peptide therapeutics, driven by AI and synthetic biology. 📅 Date: Thursday, May 7, 2026 | ⏰ Time: 10:30 – 11:30 AM EST | 📍 Link:https://lnkd.in/eUiZhKNG Dr. Xiyun Ye (JSPS Postdoctoral Fellow, University of Tokyo) will explore genetic code reprogramming for the incorporation of non-natural amino acids, unlocking new chemical space for macrocyclic peptide design. Her work demonstrates innovative strategies to engineer rigid, protease-resistant peptide backbones and expand the capabilities of mRNA display technologies for discovering high-affinity ligands against difficult targets. Dr. Genwei Zhang (Head of Peptide Platform, XtalPi) will present on AI-enabled next-generation cyclic peptide discovery, highlighting how integrated AI models, automated synthesis, and high-throughput screening are transforming the development of peptides with improved stability, permeability, and bioavailability. Learn how XtalPi's PepiX™ platform is accelerating breakthroughs across challenging targets, including CNS delivery and oral peptide therapeutics. ✅ Reserve your spot today to engage live with the speakers, get actionable insights, and stay ahead in peptide drug development. #PeptideTherapeutics #DrugDiscovery #Biotech #Pharma #AIinDrugDiscovery #Macrocycles #ChemicalBiology #LifeSciences #XtalPi

Meet XtalPi at #AACR2026 (April 17-22)! We're excited to showcase how the PepiX Platform is transforming peptide therapeutics through cutting-edge AI and high-throughput technologies. Utilizing the AI models from our PepiX™ platform, we have designed multiple peptides derived from common p53 neoantigens and demonstrated that they are strongly immunogenic under mutiple humanized allele background. These findings further support that the AI model prediction and computer assisted saturation mutagenesis is promising in modifying neo-epitopes to improve anti-tumor immunity via the CD8+ T-cell response. Together with our collaborator, we will jointly present this work in the ongoing AACR event, please find our poster#4361. How to connect with us: 📌 Don't miss our Poster #4361 at AACR (April 21, 9 AM-12 PM) ☕ Email us at pepix@xtalpi.com to pre-schedule a meeting with the XtalPi Team. #AACR2026 #AACR #PeptideDiscovery #ArtificialIntelligence #Oncology

🔚 Wrapping up an insightful week at #DDC2026 in San Diego! It's the final day of Drug Discovery Chemistry 2026, and what a powerful few days of connection, learning, and innovation it's been for the XtalPi team. We're proud to have shared our latest advancements through two poster presentations and a featured talk: ✅ Dr. Yang Xie's talk on "Beyond Serendipity: Unlocking Molecular Glue Discovery via AI and Automation" — diving into how our platform integrates AI-guided chemical space design and robotics to advance next-gen molecular glue therapies. ✅ Our poster presentations (P145 & P146) highlighting covering #VAST chemical libraries and synthesis empowered by proprietary data and robotics; and AI-driven molecular glue degrader discovery. Grateful to everyone who visited our posters and connected with the team. It has been inspiring to exchange ideas around #AIforScience, #MolecularGlue and innovative #DrugDiscovery. As DDC 2026 comes to a close, we remain committed to advancing drug discovery with AI and automation. Thank you for this valuable conference experience. #XtalPi #DDC2026 #DrugDiscoveryChemistry

🤫 We can no longer keep this a secret! The brand-new XtalGazer (the brand of XtalPi's solid state platform） website is finally live! 📢 After months of planning, drafting, rewriting, and editing, we are so excited to release the new standalone website for XtalGazer out in the wild! 🎉🚀 Whether you're working in pharma R&D, solid-state chemistry, or just XtalCurious about crystal structure prediction, we'd love for you to take a look. Go check it out here: https://www.xtalgazer.com/ Huge shoutout to everyone who helped bring this to life! #XtalPi #XtalGazer #SolidState #DrugDiscovery #AI4S #ComputationalChemistry #Pharmaceutical

Great to see such a strong addition to the Ailux team! Prof. Maria Belvisi brings exceptional scientific leadership and deep drug development expertise that will be invaluable as Ailux advances its innovative pipeline and expands globally.

We are excited to officially announce the creation of our make-on-demand, synthetically accessible chemical space: the VAST Library 🧪✨ This chemical space is Virtual, Automated, Swift, and Tailored for discovery. A high success rate (85%+), quick delivery (2–3 weeks), and competitive pricing are enabled by our automated synthesis platform and large in-stock building block collection. We have worked on VAST for almost a year, including several test orders from close partners and clients. The feedback we received on delivery success rate, novelty, and diversity has been very encouraging, and we are now excited to go live! 🎉 The fully enumerated version is available here: https://lnkd.in/eXgqWhP8 🔗, while the synthon-based representation is available under NDA.We are also in the process of integrating VAST into several platforms for chemical space navigation – stay tuned for upcoming announcements. For any questions regarding access or pricing, please contact our team at: VAST@XtalPi.com 📧

🎉XtalPi team is heading to Drug Discovery Chemistry 2026 in San Diego this April! Join us for two poster presentations: ✅ P146: Prospective Discovery of Molecular Glue Degraders Using AI-Guided Chemical Space Design and Robotics-Controlled Automated Synthesis -Presented by Yang Xie, VP, Head of Proximity Induced Therapeutics Platform ✅ P145: Agentic AI Toward Autonomous Discovery: VAST Chemical Libraries and Synthesis Enabled by Proprietary Data and Robotics -Presented by Greg Prikler, Senior Director of Business Development If you’re attending DDC 2026, let’s connect! #XtalPi #DrugDiscoveryChemistry #DDC2026 #MolecularGlue #AIforScience #BiotechInnovation