4-hydroxybenzoyl-CoA thioesterase
| 4-hydroxybenzoyl-CoA thioesterase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.1.2.23 | ||||||||
| CAS no. | 141583-19-9 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The enzyme 4-hydroxybenzoyl-CoA thioesterase (EC 3.1.2.23) catalyzes the reaction
The enzyme characterised from bacteria hydrolyses 4-hydroxybenzoyl-CoA to coenzyme A and 4-hydroxybenzoic acid, which form the thioester in the starting material. The reaction is part of a biochemical pathway that breaks down chloro-substituted benzoic acids including 4-chlorobenzoic acid in Pseudomonas species.[1][2]
This enzyme is a hydrolase, specifically one acting on thioester bonds. The systematic name is 4-hydroxybenzoyl-CoA hydrolase.[3]
Structural studies
[edit]As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes PDB: 1HN1, PDB: 1LO7, PDB: 1LO8, PDB: 1LO9, PDB: 1Q4S, PDB: 1Q4T, and PDB: 1Q4U. The enzyme contains a so-called HotDog domain.[4][5]
References
[edit]- ↑ Chang KH, Liang PH, Beck W, Scholten JD, Dunaway-Mariano D (1992). "Isolation and characterization of the three polypeptide components of 4-chlorobenzoate dehalogenase from Pseudomonas sp. strain CBS-3". Biochemistry. 31 (24): 5605–10. doi:10.1021/bi00139a025. PMID 1610806.
- ↑ Dunaway-Mariano D, Babbitt PC (1994). "On the origins and functions of the enzymes of the 4-chlorobenzoate to 4-hydroxybenzoate converting pathway". Biodegradation. 5 (3–4): 259–76. doi:10.1007/BF00696464. PMID 7765837. S2CID 13250105.
- ↑ Enzyme 3.1.2.23 at KEGG Pathway Database.
- ↑ Dillon, Shane C.; Bateman, Alex (2004). "The Hotdog fold: Wrapping up a superfamily of thioesterases and dehydratases". BMC Bioinformatics. 5 109. doi:10.1186/1471-2105-5-109. PMC 516016. PMID 15307895.
- ↑ Song, Feng; Thoden, James B.; Zhuang, Zhihao; Latham, John; Trujillo, Michael; Holden, Hazel M.; Dunaway-Mariano, Debra (2012). "The Catalytic Mechanism of the Hotdog-fold Enzyme Superfamily 4-Hydroxybenzoyl-CoA Thioesterase from Arthrobacter sp. Strain SU". Biochemistry. 51 (35): 7000–7016. doi:10.1021/bi301059m. PMC 4710518. PMID 22873756.
