Malate dehydrogenase (NADP+)
| malate dehydrogenase (NADP+) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Malate dehydrogenase (NADP+) homodimer, Flaveria bidentis | |||||||||
| Identifiers | |||||||||
| EC no. | 1.1.1.82 | ||||||||
| CAS no. | 37250-19-4 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Malate dehydrogenases (NADP+) (EC 1.1.1.82) are a type of light-sensitive enzyme found in plants[1] that catalyze the chemical reaction
The two substrates of this enzyme are (S)-malic acid and oxidised nicotinamide adenine dinucleotide phosphate (NADP+). Its products are oxaloacetic acid, NADPH, and a proton.[2][3][4][5]
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-malate:NADP+ oxidoreductase. Other names in common use include NADP+-malic enzyme, NADP+-malate dehydrogenase, malic dehydrogenase (nicotinamide adenine dinucleotide phosphate), malate NADP+ dehydrogenase, NADP+ malate dehydrogenase, NADP+-linked malate dehydrogenase, and malate dehydrogenase (NADP+). This enzyme participates in pyruvate metabolism and carbon fixation. This enzyme has at least one effector, hn.
Structural studies
[edit]As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes PDB: 1CIV and PDB: 7MDH.
References
[edit]- ↑ EC 1.1.1.82
- ↑ Enzyme 1.1.1.82 at KEGG Pathway Database.
- ↑ Connelly JL, Danner DJ, Bowden JA (1968). "Branched chain alpha-keto acid metabolism. I. Isolation, purification, and partial characterization of bovine liver alpha-ketoisocaproic:alpha-keto-beta-methylvaleric acid dehydrogenase". J. Biol. Chem. 243 (6): 1198–203. doi:10.1016/S0021-9258(19)56972-1. PMID 5689906.
- ↑ Johnson HS (1971). "NADP-malate dehydrogenase: photoactivation in leaves of plants with Calvin cycle photosynthesis". Biochem. Biophys. Res. Commun. 43 (4): 703–9. Bibcode:1971BBRC...43..703J. doi:10.1016/0006-291X(71)90672-3. PMID 4397919.
- ↑ Johnson HS, Hatch MD (1970). "Properties and regulation of leaf nicotinamide–adenine dinucleotide phosphate–malate dehydrogenase and 'malic' enzyme in plants with the C4-dicarboxylic acid pathway of photosynthesis". Biochem. J. 119 (2): 273–80. doi:10.1042/bj1190273. PMC 1179348. PMID 4395182.
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