User talk:Doc James

Note: Mostly over at MDWiki:Main_Page and Commons.

Image

Hi there, please can you modify or remove this illustration? It incorrectly depicts a measles virus in the environment binding to the surface of an epithelial cell. However initial infection targets macrophages in the lining of the airways. In a later stage of infection, the virus infects epithelial cells but fuses to the binding protein nectin-4 having been transported in the bloodstream.

Thanks!! Bob (talk) 20:09, 6 August 2026 (UTC) Bob (talk) 20:09, 6 August 2026 (UTC)

Yes appears understanding has changed from:

"The current model of measles virus (MV) pathogenesis implies that apical infection of airway epithelial cells precedes systemic spread." to

"MeV does not directly infect epithelial cells upon entry in a new host. MeV traverses the epithelium within immune cells that carry it to lymphatic organs where amplification occurs. Infected immune cells then synchronously deliver large amounts of virus to the airways."

Doc James (talk · contribs · email) 20:30, 6 August 2026 (UTC)

It does use SLAMF1 to attach to macrophages and it does use nectin-4 for epithelial cells eventually.

Text of the videoscript is thus dated aswell. I guess the question is what should we update it to? Doc James (talk · contribs · email) 20:35, 6 August 2026 (UTC)

Apologies for late reply, I wasn't monitoring your talk page. I'm not sure how easy it is to change an illustration ..... I would suggest adding a macrophage straddling the epithelial cells, being attacked by the virion. I was hoping to find something similar in Wikimedia but I'm short of time!

Bob (talk) 09:24, 3 September 2026 (UTC)

And how do you think we should update the text? Should the macrophage be on top of the epithelial cells or between them? Doc James (talk · contribs · email) 10:47, 3 September 2026 (UTC)

@Doc James - I'm well out of my depth here, I'm sure you have better sources than I do. I found a couple of micrographs - one shows between, the other shows on top, so take your pick. Halfway?? Bob (talk) 22:08, 3 September 2026 (UTC)

User:Robertpedley Something like this? If you agree can get someone to make a better version. Doc James (talk · contribs · email) 08:57, 4 September 2026 (UTC)

Yes, I think that would do it nicely. Many thanks!! Bob (talk) 21:11, 7 September 2026 (UTC)

MDWiki is down

https://mdwiki.org/wiki/Main_Page now returns 500 error. GZWDer (talk) 09:07, 11 October 2026 (UTC)

Thanks, yes we keep getting taken down by AI spiders. It is up again. Hopefully we will figure out a long term fix soon. Doc James (talk · contribs · email) 18:39, 11 October 2026 (UTC)

Down again. GZWDer (talk) 14:27, 12 October 2026 (UTC)

Yah, we have updated the translation dashboard so at least know it should work even if MDWiki is down. Doc James (talk · contribs · email) 18:23, 12 October 2026 (UTC)

The Signpost: 13 October 2026

• News and notes: AELECT returns, Jimbo gives a union update, VisualEditor is now default
  Plus a survey for North Americans, proposed changes to BoT elections, and developments in the Puerto Rican editing community.

• Serendipity: From a rare portrait of a female millionaire in Nancy to a Japanese painter in Lyon
  Images from Leuven Libraries popular on Wiki.

• Obituary: Doug Weller
  Twenty-year editor, long-term admin, dearly missed.

• In the media: A(I)pocalypses afoot
  Cannibals, freeloaders, rogue agents, scams ... the usual.

• WikiConference Report: WikiConference 2026 & the importance of in-person community
  Celebrating 12 years of WikiConference North America.

• By the numbers: Does the country of birth affect the likelihood of having a Wikipedia biography?
  A cross-country and cross-wikipedia comparison of the likelihood of having a biography in Wikipedia.

• News from Diff: OpenAI "rogue" agent activities found on Wikimedia projects
  CPO/CTO Selena Deckelmann explains the recent detection of AI agent activities on Wikimedia projects.

• On the bright side: Good people
  Nice comments and real-life rescuers.

• Op-ed: Who are our readers?
  The movement makes progress when we know what our scope is.

• Traffic report: This world is big and wild and half insane
  Criminals, 9/11 25 years later, artists expelled for politics... we lived in troubled times.

• Comix: Fudging the numbers
  Take 'em away, officers!

* Read this Signpost in full * Single-page * Unsubscribe * MediaWiki message delivery (talk) 22:43, 13 October 2026 (UTC)

Request of Arbitration opened

You are involved in a recently filed request for arbitration. Please review the request at Wikipedia:Arbitration/Requests/Case#Airlines and Aviation and, if you wish to do so, enter your statement and any other material you wish to submit to the Arbitration Committee. As threaded discussion is not permitted on most arbitration pages, please ensure that you make all comments in your own section only. Additionally, the guide to arbitration and the Arbitration Committee's procedures may be of use. Star Mississippi 03:17, 21 October 2026 (UTC)