HRAS

HRAS
Structures disponibles PDB Recherche d'orthologue : PDBe RCSB Identifiants PDB 121P, 1AA9, 1AGP, 1BKD, 1CLU, 1CRP, 1CRQ, 1CRR, 1CTQ, 1GNP, 1GNQ, 1GNR, 1HE8, 1IAQ, 1IOZ, 1JAH, 1JAI, 1K8R, 1LF0, 1LF5, 1LFD, 1NVU, 1NVV, 1NVW, 1NVX, 1P2S, 1P2T, 1P2U, 1P2V, 1PLJ, 1PLK, 1PLL, 1Q21, 1QRA, 1RVD, 1WQ1, 1XCM, 1XD2, 1XJ0, 1ZVQ, 1ZW6, 221P, 2C5L, 2CE2, 2CL0, 2CL6, 2CL7, 2CLC, 2CLD, 2EVW, 2LCF, 2LWI, 2Q21, 2QUZ, 2RGA, 2RGB, 2RGC, 2RGD, 2RGE, 2RGG, 2UZI, 2VH5, 2X1V, 3DDC, 3I3S, 3K8Y, 3K9L, 3K9N, 3KKM, 3KKN, 3KUD, 3L8Y, 3L8Z, 3LBH, 3LBI, 3LBN, 3LO5, 3OIU, 3OIV, 3OIW, 3RRY, 3RRZ, 3RS0, 3RS2, 3RS3, 3RS4, 3RS5, 3RS7, 3RSL, 3RSO, 421P, 4DLR, 4DLS, 4DLT, 4DLU, 4DLV, 4DLW, 4DLX, 4DLY, 4DLZ, 4EFL, 4EFM, 4EFN, 4G0N, 4G3X, 4K81, 4Q21, 521P, 5P21, 621P, 6Q21, 721P, 821P, 4L9S, 4L9W, 4NYI, 4NYJ, 4NYM, 4URU, 4URV, 4URW, 4URX, 4URY, 4URZ, 4US0, 4US1, 4US2, 2N42, 2N46, 4XVQ, 4XVR, 4RSG, 5B30
Identifiants
Alias	HRAS
IDs externes	OMIM: 190020 MGI: 96224 HomoloGene: 55890 GeneCards: HRAS
Nomenclature EC	3.6.5.2
Position du gène (humain) Chr. Chromosome 11 humain Locus 11p15.5 Début 532,242 bp Fin 537,321 bp
Position du gène (souris) Chr. Chromosome 7 (souris) Locus 7 F5|7 86.48 cM Début 140,769,018 bp Fin 140,773,918 bp
Expression génique Bgee Humain Souris (orthologue) Fortement exprimé dans skin of abdomen skin of leg putamen noyau caudé noyau accumbens hypothalamus lobe temporal amygdale right hemisphere of cerebellum substantia nigra Fortement exprimé dans dentate gyrus of hippocampal formation granule cell lèvre molaire gyrus frontal supérieur œsophage fetal liver hematopoietic progenitor cell Vésicule vitelline cortex entorhinal Cortex périrhinal muscle de la cuisse Plus de données d'expression de référence BioGPS Plus de données d'expression de référence
Gene Ontology Fonction moléculaire liaison nucléotide protein C-terminus binding liaison protéique GTPase activity GTP binding GDP binding Composant cellulaire cytoplasme cytosol appareil de Golgi intracellular membrane-bounded organelle membrane Golgi membrane membrane plasmique perinuclear region of cytoplasm noyau glutamatergic synapse Processus biologique negative regulation of neuron apoptotic process defense response to protozoan positive regulation of protein phosphorylation regulation of long-term neuronal synaptic plasticity endocytose positive regulation of MAP kinase activity positive regulation of miRNA metabolic process positive regulation of epithelial cell proliferation positive regulation of ruffle assembly mitotic cell cycle checkpoint signaling positive regulation of cell migration ephrin receptor signaling pathway positive regulation of wound healing positive regulation of Ras protein signal transduction positive regulation of interferon-gamma production stimulatory C-type lectin receptor signaling pathway positive regulation of JNK cascade negative regulation of gene expression MAPK cascade intrinsic apoptotic signaling pathway positive regulation of GTPase activity chimiotaxie cell surface receptor signaling pathway positive regulation of gene expression negative regulation of GTPase activity positive regulation of cell population proliferation positive regulation of ERK1 and ERK2 cascade morphogenèse d'un organe animal T-helper 1 type immune response Ras protein signal transduction prolifération cellulaire T cell receptor signaling pathway positive regulation of actin cytoskeleton reorganization positive regulation of MAPK cascade negative regulation of cell population proliferation positive regulation of transcription by RNA polymerase II transduction de signal apoptose small GTPase mediated signal transduction sénescence cellulaire response to isolation stress cellular response to gamma radiation positive regulation of DNA replication positive regulation of phospholipase C activity protein heterooligomerization positive regulation of protein targeting to membrane regulation of neurotransmitter receptor localization to postsynaptic specialization membrane Sources:Amigo / QuickGO
Orthologues Espèces Homme Souris Entrez 3265 15461 Ensembl ENSG00000276536 ENSG00000174775 ENSMUSG00000025499 UniProt P01112 Q61411 RefSeq (mRNA) NM_001130442 NM_005343 NM_176795 NM_001318054 NM_001130443 NM_001130444 NM_008284 RefSeq (protéine) NP_001123914 NP_001304983 NP_005334 NP_789765 NP_001123915 NP_001123916 NP_032310 Localisation (UCSC) Chr 11: 0.53 – 0.54 Mb Chr 7: 140.77 – 140.77 Mb Publication PubMed
Wikidata
Voir/Editer Humain Voir/Editer Souris

HRAS est un gène situé sur le chromosome 11 humain.

Maladies liées

• Syndrome de Costello
• Cancer différencié de la thyroïde
• Cheveux laineux sur naevus
• Phacomatose pigmento-kératosique
• Syndrome du naevus sébacé linéaire