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Lithium Treatment of Chronic Cluster Headaches

Published online by Cambridge University Press:  29 January 2018

Julian Lieb  and
Arnold Zeff
Julian Lieb
Affiliation:
Yale University School of Medicine, and Director, The Dana Psychiatric Clinic, Yale–New Haven Hospital, 789 Howard Avenue, New Haven, Connecticut, U.S.A. 06504
Arnold Zeff
Affiliation:
Yale University School of Medicine
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Summary

On the basis of reports of reduced MAO activity in migraine and cluster headaches and on a report that lithium carbonate activates MAO, the authors administered lithium carbonate to two patients whose cluster headaches had brought them to the point of contemplating suicide. Both patients responded quite dramatically. Case 1 has now been virtually free of headaches for over two years and Case 2 has been in remission for over twelve months.

Information

Type
Research Article
Information
The British Journal of Psychiatry , Volume 133 , Issue 6 , December 1978 , pp. 556 - 558
Copyright
Copyright © Royal College of Psychiatrists, 1978 

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References

Anthony, M. & Lance, J. W. (1969) Monoamine oxidase inhibition in the treatment of migraine. Archives of Neurology, 21, 263–8.Google Scholar
Bockar, J., Roth, R. & Heninger, G. (1974) Increased human platelet monoamine oxidase activity during lithium carbonate therapy. Life Sciences, 15, 2109–18.Google Scholar
Couch, J. R., Ziegler, D. K. & Hassanien, R. S. (1974) Evaluation of amitriptyline in migraine prophylaxis. Transactions of the American Neurological Association, 99, 94–8.Google Scholar
Couch, J. R., Ziegler, D. K. & Hassanien, R. S. (1976) Amitriptyline in the prophylaxis of migraine. Neurology, 26, 121–7.Google Scholar
Damasio, H. & Beck, D. (1978) Migraine, thrombocytopenia and serotonin metabolism. Lancet, i, 240–1.Google Scholar
Dexter, J. & Weitzman, E. D. (1970) The relationship of nocturnal headaches to sleep stage patterns. Neurology (Minneapolis), 20, 513–18.Google Scholar
Ekbom, K. (1977) Lithium in the treatment of chronic cluster headache. Headache, 17, 39–40.Google Scholar
Glover, V., Sandler, M. & Grant, E. et al (1977) Transitory decrease in platelet monoamine-oxidase activity during migraine attacks. Lancet, i, 391–3.Google Scholar
Herberg, J. (1975) The hypothalamus and aminergic pathways in migraine. In Topics in Migraine (ed. Pearce, J.), pp. 85–95. London: Heinemann.Google Scholar
Kudrow, L. (1977) Lithium prophylaxis for chronic cluster headache. Headache, 17, 15–18.Google Scholar
Kupfer, D. J., Wyatt, R. J. & Greenspan, K. et al (1970) Lithium carbonate and sleep in affective illness. Archives of General Psychiatry, 23, 35–40.Google Scholar
Mendels, J. & Chernik, D. A. (1973) The effect of lithium carbonate on the sleep of depressed patients. International Pharmacopsychiatry, 8, 184–92.Google Scholar
Sandler, M., Youdim, M. B. & Hanington, E. (1974) A phenylethylamine oxidising defect in migraine. Nature, 350, 335–7.Google Scholar
Sullivan, J. L., Dackis, C. & Stanfield, C. (1977) In vivo inhibition of platelet MAO activity by tricyclic antidepressants. American Journal of Psychiatry, 134, 188–90.Google Scholar

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